The Allahabad Medical Association was born in 1918 at the residence of Major B.D. Basu when a handful of doctors got together to form a Doctor's Club. Prominent amongst those present on that fateful day (besides Major Basu) were Major Des Raj, Dr. Ranjit Singh, Dr. A.C. Banerji and Dr. R.N. Banerji. The Association so formed was registered as "Allahabad Medical Association" and it is notable that the Indian Medical Association (or IMA) came into being only in 1928.

Thus Allahabad Medical Association, or "AMA" as it is popularly called, predates its parent body by a good 10 years and for this reason it is allowed to continue its original registered name rather than being called "the Allahabad Branch of Indian Medical Association", as would otherwise have been in case. Initially, the Doctor's Club, or AMA functioned from the residence of Major Basu, situated at Bahudurganj but later shifted to Elgin Road at the residence of Prof. Chowdhary primarily in order to avoid the congestion of Bahadurganj. It was from this office that AMA functioned till 2001 when it moved to its current location at 29 Stanley Road.

On 10th March 1980, a philanthropist, Sri Madanlal Ahuja donated 2883 Sq. yds land to AMA along with funds for setting up a charitable dispensary at 29 Stanley Road Allahabad facilitated largely by the efforts of the then President of AMA, Dr. A.K. Ghosh. Unfortunately, a major portion of this land has since been encroached upon and only about 950 Sq yds remain in possession of AMA. However due to the untiring efforts of several members, the entire land has been converted to free hold in favour of AMA in 2008 and efforts are on to get back possession of the encroached portion. It is from this address that AMA and the prestigious blood bank run by it, now functions.

In 1993, a UP State Conference was organized by AMA which generated a surplus fund of Rs. 2 lacs. The two halls of the present building were built in 1994 and in 1995 the first annual medical education meet or CME, as they are called, was organized by AMA - an event that is now continuing every year since then, without break.

The first Blood Bank project was taken up in 1995, but it was only in the year 2000 that is was pursued earnestly. An initial corpus of Rs. 15 lacs was generated largely with the help of donation of Rs. 5 lacs each from two philanthropist gentleman of the city (who incidentally are the permanent invitee members of the Blood Bank Committee, entrusted with the task of running the Blood Bank), donations from AMA members and savings from AMA funds. The license for the Blood Bank was received on 7-4-2003 a red letter day in the history of AMA and within two years. on 13-5-2005, license for setting up a "Component Separation Unit" was granted to AMA. In 2008, license for apheresis – which gives facility for taking platelets from a single donor rather than from several donors was also received. The AMA Blood Bank is providing yeomen services to the citizens of Allahabad and has saved many precious lives, having dispensed more that 5,40,000 units of blood and components since inception. An ambulance service with the three ambulances is also currently operating on no-profit, no-loss basis. AMA has also adopted a village and holds regular health camps there for the benefit of needy villagers. It has also constructed three toilets in girl’s schools in villages as contribution towards the Swachh Bharat Abhiyan. It also holds free health camps for pilgrims every year through out the duration of the annual Kumbh Mela, providing free consultation and medicines to the needy.